How Does NexGard for Dogs Work?

NexGard is a widely-used oral flea and tick medication for dogs, but how exactly does it work? In this article, we’ll delve into the mechanism of action of NexGard and explore its effectiveness in protecting our canine companions from pesky parasites.

Introduction to NexGard for Dogs

NexGard is a prescription-strength flea and tick treatment designed to eliminate existing infestations and prevent future ones in dogs. It comes in the form of a chewable tablet, making it convenient and easy to administer.

Understanding NexGard: How Does it Work?

NexGard works by utilizing an active ingredient called Afoxolaner, which belongs to the class of isoxazoline compounds. Afoxolaner targets the nervous system of fleas and ticks, disrupting their neurotransmission and ultimately leading to paralysis and death.

Active Ingredient: Afoxolaner

Afoxolaner works by binding to specific receptors in the nervous system of fleas and ticks, known as gamma-aminobutyric acid (GABA) and glutamate receptors. This binding interferes with the normal function of these receptors, causing hyperexcitation and paralysis in the parasites.

Mode of Action

Once ingested, NexGard is rapidly absorbed into the bloodstream, reaching peak concentrations within hours. As fleas and ticks feed on the dog’s blood, they ingest the Afoxolaner present in NexGard, leading to rapid paralysis and death of the parasites.

Benefits of NexGard

– Effective against fleas and ticks

– Provides month-long protection with a single dose

– Easy to administer

– Starts working within hours of ingestion

Administration and Dosage

NexGard for dogs should be administered orally once a month, with or without food. The dosage is based on the dog’s weight, and it’s essential to follow the veterinarian’s instructions carefully to ensure proper dosing and effectiveness.

Safety Considerations

NexGard is generally safe for most dogs, but some precautions should be taken. It’s essential to consult with your veterinarian before administering NexGard, especially in dogs with a history of seizures or sensitivity to the medication.

NexGard vs. Other Flea and Tick Treatments

NexGard offers several advantages over other flea and tick treatments, including its fast-acting formula, ease of administration, and month-long protection with a single dose. Additionally, NexGard is suitable for use in puppies as young as 8 weeks old.

NexGard for Puppies

NexGard is safe for use in puppies as young as 8 weeks old and weighing at least 4 pounds. It provides effective protection against fleas and ticks, helping puppies grow up healthy and parasite-free.

NexGard for Adult Dogs

Adult dogs can also benefit from NexGard’s powerful flea and tick protection. Whether your dog spends time indoors or outdoors, NexGard offers peace of mind knowing your furry friend is protected from pesky parasites.

Potential Side Effects

While NexGard is generally well-tolerated, some dogs may experience mild side effects such as vomiting, diarrhea, or lethargy. These side effects are usually temporary and resolve on their own. However, if they persist or worsen, it’s essential to consult with your veterinarian.


NexGard is a highly effective flea and tick treatment for dogs, thanks to its innovative formula and fast-acting mechanism of action. By understanding how NexGard works and following proper administration guidelines, pet owners can ensure their dogs remain protected from fleas and ticks all year round.

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