Frontline Plus for Cats: A Complete Guide

What is Frontline Plus?

Frontline Plus is a popular and trusted flea and tick treatment for cats. It is a topical solution that is applied directly to the skin, providing long-lasting protection against fleas, ticks, and chewing lice.


Frontline Plus for cats contains two active ingredients: fipronil and (S)-methoprene.

How it works:

Fipronil kills adult fleas and ticks by targeting their nervous system, while (S)-methoprene inhibits the development of flea eggs and larvae, breaking the flea life cycle.


  • Provides fast-acting and long-lasting protection
  • Kills fleas within 12 hours and ticks within 48 hours
  • Waterproof formula

How to Apply Frontline Plus

Applying Frontline Plus to your cat is simple and straightforward. Follow these steps for effective application:

  1. Choose the Right Dose:
    Frontline Plus is available in different doses based on your cat’s weight. Make sure to select the appropriate dose for your cat.
  2. Prepare the Applicator:
    Remove the applicator from the package and hold it upright. Tap the narrow part of the applicator to ensure the contents are in the main body of the applicator.
  3. Part Your Cat’s Fur:
    Part the fur on the back of your cat’s neck, between the shoulder blades, to expose the skin.
  4. Apply the Solution:
    Place the tip of the applicator on the skin and squeeze the entire contents directly onto the skin in one spot.
  5. Discard the Applicator:
    Dispose of the empty applicator as per local regulations.
  6. Keep Your Cat Dry:
    Ensure your cat does not get wet for at least 24 hours after application.

Dosage and Frequency:

Frontline Plus should be applied once a month for continuous protection. The dosage depends on your cat’s weight, so make sure to follow the instructions on the packaging.

Effectiveness of Frontline Plus

Duration of Action:

Frontline Plus provides protection against fleas for up to one month and against ticks for up to two weeks.

Efficacy against Fleas and Ticks:

Frontline Plus is highly effective at killing fleas and ticks. It starts working within 12 hours of application, killing fleas before they can lay eggs, and it kills ticks within 48 hours.

Safety Considerations

Side Effects:

While Frontline Plus is generally safe for most cats, some may experience mild side effects such as skin irritation or hair loss at the application site.


  • Do not use Frontline Plus on kittens under 8 weeks of age.
  • Avoid contact with the eyes and mouth.
  • Keep treated pets away from other pets and children until the application site is dry.

Alternatives to Frontline Plus

There are several alternatives to Frontline Plus available on the market, including oral medications and other topical treatments. Some popular alternatives include Advantage, Revolution, and Seresto collars.

Comparison with Other Flea and Tick Treatments:

While each product has its own pros and cons, Frontline Plus is preferred by many cat owners for its ease of application and effectiveness.

Where to Buy Frontline Plus

Frontline Plus for cats is available for purchase online and at pet stores and veterinary clinics. Prices may vary depending on the retailer and the size of the package.

Online and Offline Options:

  • Pet stores (PetSmart, Petco)
  • Veterinary clinics
  • Online retailers (Amazon, Chewy)


The cost of Frontline Plus varies depending on the size of the package and where you purchase it.

Customer Reviews

Positive Feedback:

  • “Frontline Plus has been a game-changer for my cat. No more fleas or ticks!”
  • “I love that Frontline Plus is waterproof. I don’t have to worry about reapplying after my cat goes outside in the rain.”

Negative Feedback:

  • “My cat had a bad reaction to Frontline Plus. Her fur fell out at the application site.”
  • “Frontline Plus is expensive compared to other flea treatments.”


How often should I apply Frontline Plus?

    Frontline Plus should be applied once a month for continuous protection.

    Can Frontline Plus be used on kittens?

      Frontline Plus should not be used on kittens under 8 weeks of age.

      Is Frontline Plus waterproof?

        Yes, Frontline Plus is waterproof after 24 hours.

        What should I do if my cat licks Frontline Plus?

          If your cat licks Frontline Plus, monitor them for any signs of adverse reactions and contact your veterinarian if necessary.

          How long does it take for Frontline Plus to work?

            Frontline Plus starts working within 12 hours of application, killing fleas before they can lay eggs, and it kills ticks within 48 hours.


            Frontline Plus is a highly effective and convenient flea and tick treatment for cats. With its fast-acting formula and long-lasting protection, it’s no wonder why so many cat owners trust Frontline Plus to keep their furry friends safe and healthy.

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